منابع مشابه
Hepatotoxic effects of tert-butyl hydroperoxide (t-BHP) and protection by antioxidants.
t-BHP induced oxidative stress and Ca2+ function impairment in fresh hepatocytes was studied in order to understand its role in cytotoxicity. Viability of hepatocytes by the release of lactate dehydrogenase and methyl thiazoletetrazolium reduction method alongwith malondialdehyde formation indicated oxidative stress in the hepatotoxic action of t-BHP.
متن کاملProtective effect of ellagic acid on t-butyl hydroperoxide induced lipid peroxidation in isolated rat hepatocytes.
Ellagic acid, a plant polyphenol, showed protective effect on isolated rat hepatocytes against destruction due to lipid peroxide formation induced by t-butyl hydroperoxide in vitro. Ellagic acid inhibited the generation of superoxide anions and hydroxyl radicals both in enzymic and non enzymic systems, thus providing protection against oxidative damage.
متن کاملGene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells.
Global gene expression patterns in breast cancer cells after treatment with oxidants (hydrogen peroxide, menadione, and t-butyl hydroperoxide) were investigated in three replicate experiments. RNA collected after treatment (at 1, 3, 7, and 24 h) rather than after a single time point, enabled an analysis of gene expression patterns. Using a 17,000 microarray, template-based clustering and multid...
متن کاملChemiluminescence studies of reaction between luminol and T-butyl hydroperoxide in presence of some nsaids
The Chemiluminescence (CL) that accompanies the oxidation of luminol with tert-butyl hydroperoxide (t-BuOOH) in alkaline medium was studied. The reaction occurring between luminol and t-BuOOH in alkaline medium leads to the production of nitrogen gas with simultaneous emission of CL. The effect of non-steroidal anti-inflammatory drugs (NSAIDS) like aspirin and ibuprofen has also been studied. T...
متن کاملInhibitory effect of t-butyl hydroperoxide on mitochondrial oxidative phosphorylation in isolated rat hepatocytes.
Using high-resolution oxygraphy, we tested the changes of various parameters characterizing the mitochondrial energy provision system that were induced by peroxidative damage. In the presence of succinate as respiratory substrate, 3 mM t-butyl hydroperoxide increased respiration in the absence of ADP, which indicated partial uncoupling of oxidative phosphorylation. Low activity of coupled respi...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1994
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.52.72